Interactions of Ginkgolides A and B with a Recombinant Human Prion Protein

In the presence of ginkgolides A and B a recombinant human prion protein (90-231) is more susceptible to proteolysis, which is characteristic for the non-infective form of prion proteins and more thermostable than in the absence of ginkgolides. Probably, ginkgolides exert a neuroprotective effect through a rearrangement of the prion structure. Keywords: Three-dimensional structure, structural transformation, ginkgolide, prion protein, protein misfolding