黄檀
辣根过氧化物酶
自愈水凝胶
生物相容性
肿胀 的
酪胺
共轭体系
过氧化氢
材料科学
化学
高分子化学
化学工程
有机化学
聚合物
生物化学
酶
食品科学
复合材料
工程类
作者
Moslem Tavakol,Ebrahim Vasheghani‐Farahani,Mohammad Amin Mohammadifar,Masoud Soleimani,Sameereh Hashemi‐Najafabadi
标识
DOI:10.1177/0885328215608983
摘要
In this study, an enzyme catalyzed in situ forming hydrogel based on tyramine conjugated high methoxyl content gum tragacanth (TA-HMGT) was prepared and characterized. TA-HMGT was synthesized via heterogeneous ammonolysis of methyl ester groups of HMGT. Then, the hydrogel was prepared via horseradish peroxidase catalyzed coupling reaction in the presence of hydrogen peroxide. Hydrogel properties, such as gelation time, swelling/degradation behavior and rheological properties could be adjusted by tuning the gelation parameters and extent of tyramine conjugation. This system was a soft elastic hydrogel with appropriate biocompatibility. The fast gelation of the hydrogel is desirable for clinical applications. Also, in vitro bovine serum albumin release from the synthesized hydrogel showed good release profile with limited burst release.
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