生物
癌症研究
DiGeorge综合征
基因
调节器
癌变
长非编码RNA
转录因子
基因表达调控
作者
Haoming Xia,Ziyue Huang,Shuqiang Liu,Xudong Zhao,Risheng He,Zhongrui Wang,Wenguang Shi,Wangming Chen,Zhizhou Li,Liang Yu,Peng Huang,Pengcheng Kang,Zhilei Su,Yi Xu,Judy Wai Ping Yam,Yunfu Cui
标识
DOI:10.1016/j.biopha.2021.111889
摘要
Long non-coding RNA (lncRNA), a subgroup of ncRNA with a length of more than 200 nt without protein coding function, has been recognized by the academia for its mediating effects of dysregulated expression on the tumorigenesis and development of a variety of tumors. LncRNA DiGeorge syndrome critical region gene 5 (DGCR5), originally found to induce DiGeorge syndrome, has been confirmed to be extremely dysregulated in multiple tumors, which mediates the malignant phenotypes of hepatocellular carcinoma, pancreatic cancer, lung cancer, etc. through the regulation of Wnt/β-catenin, MEK/ERK1/2 and other cancerous signaling pathways as a molecular sponge. Researches on the cancerous derivation-related pathways involved in DGCR5 can provide potential molecular intervention targets for tumor precision treatment. Moreover, liquid biopsy based on the detection of DGCR5 in body fluids is also expected to provide a non-invasive evaluation method for the early diagnosis and prognostic evaluation of malignant tumors.
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