包装D1
常染色体显性多囊肾病
生物
囊肿
肾
多囊肾病
细胞生物学
肾脏疾病
病理
内分泌学
内科学
癌症研究
医学
作者
Ke Dong,Chao Zhang,Xin Tian,Daniel Coman,Fahmeed Hyder,Ming Ma,Stefan Somlo
出处
期刊:Nature Genetics
[Springer Nature]
日期:2021-10-11
卷期号:53 (12): 1649-1663
被引量:56
标识
DOI:10.1038/s41588-021-00946-4
摘要
Initiation of cyst formation in autosomal dominant polycystic kidney disease (ADPKD) occurs when kidney tubule cells are rendered null for either PKD1 or PKD2 by somatic ‘second hit’ mutations. Subsequent cyst progression remodels the organ through changes in tubule cell shape, proliferation and secretion. The kidney develops inflammation and fibrosis. We constructed a mouse model in which adult inactivation of either Pkd gene can be followed by reactivation of the gene at a later time. Using this model, we show that re-expression of Pkd genes in cystic kidneys results in rapid reversal of ADPKD. Cyst cell proliferation is reduced, autophagy is activated and cystic tubules with expanded lumina lined by squamoid cells revert to normal lumina lined by cuboidal cells. Increases in inflammation, extracellular matrix deposition and myofibroblast activation are reversed, and the kidneys become smaller. We conclude that phenotypic features of ADPKD are reversible and that the kidney has an unexpected capacity for plasticity controlled at least in part by ADPKD gene function. Re-expression of Pkd genes in cystic kidneys results in rapid reversal of autosomal dominant polycystic kidney disease phenotypes in mice, revealing an unexpected capacity for renal plasticity under the control of Pkd gene function.
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