Is it anemia an independent prognostic factor of patients with renal cell carcinoma? A university hospital experience.

e16501 Background: Clear cell carcinoma (RCC) is the most common histologic type of renal cancer. It is well established that, for this specific histology, six main prognostic factors interact into a score and can categorize it into three different prognostic groups: favorable-risk, intermediate-risk, and poor-risk. These six factors are anemia, thrombocytosis, neutrophilia, hypercalcemia, Karnofsky performance status < 80%, and < 1 year from diagnosis to treatment. The objective of this study is to evaluate if any of these prognostic factors can independently predict a worse prognosis. Methods: We conducted a retrospective study with 51 patients treated in our national reference institution. The great majority of them were RCC. We analyzed the overall survival (OS) of each one of the six classic risk factors adding to that the body mass index (BMI), the presence of metastasis at diagnosis time, and comorbidities. Results: The analysis of most of the indexed parameters did not show a statistical difference, but anemia and the presence of metastasis at the time of diagnosis. We found that the anemia itself denotes a Hazard Ratio (HR) of 2,35 (p = 0,034). Moreover, if it is adjusted for age and sex, the HR reduces at 1,149, sustaining its statistical significance yet. The presence of metastasis at the time of diagnosis is translated as an HR = 2,029 (p = 0,049), bringing into light something already known in clinical practice, but still, a lower risk compared to anemia. Conclusions: The six classic risk factors for RRC survival pooled together can interact and predict the OS and patient’s prognosis. Our study suggests that the anemia itself can predict independently a worst-case scenario, which emphasizes the importance of this analysis upfront. A larger prospective cohort is warranted to further understanding this framework.