Defluorinative [4 + 1] annulation of perfluoroalkyl N-mesylhydrazones with primary amines provides 5-fluoroalkyl 1,2,3-triazoles

A novel azide-free approach for the synthesis of 5-perfluoroalkyl-1,2,3-triazoles via the [4 + 1] annulation of perfluoroalkyl N -mesylhydrazones (PFHZ-Ms) with primary amines was realized under mild conditions.