Microbial cell factories for the production of polyhydroxyalkanoates

羟基烷酸 生物塑料 钩虫贪铜菌 聚羟基丁酸酯 极端微生物 微生物 生物技术 微生物降解 细菌 生物 生态学 遗传学
作者
Dillirani Nagarajan,Ganies Riza Aristya,Yu‐Ju Lin,Jui-Jen Chang,Hong‐Wei Yen,Jo‐Shu Chang
出处
期刊:Essays in Biochemistry [Portland Press]
卷期号:65 (2): 337-353 被引量:20
标识
DOI:10.1042/ebc20200142
摘要

Abstract Pollution caused by persistent petro-plastics is the most pressing problem currently, with 8 million tons of plastic waste dumped annually in the oceans. Plastic waste management is not systematized in many countries, because it is laborious and expensive with secondary pollution hazards. Bioplastics, synthesized by microorganisms, are viable alternatives to petrochemical-based thermoplastics due to their biodegradable nature. Polyhydroxyalkanoates (PHAs) are a structurally and functionally diverse group of storage polymers synthesized by many microorganisms, including bacteria and Archaea. Some of the most important PHA accumulating bacteria include Cupriavidus necator, Burkholderia sacchari, Pseudomonas sp., Bacillus sp., recombinant Escherichia coli, and certain halophilic extremophiles. PHAs are synthesized by specialized PHA polymerases with assorted monomers derived from the cellular metabolite pool. In the natural cycle of cellular growth, PHAs are depolymerized by the native host for carbon and energy. The presence of these microbial PHA depolymerases in natural niches is responsible for the degradation of bioplastics. Polyhydroxybutyrate (PHB) is the most common PHA with desirable thermoplastic-like properties. PHAs have widespread applications in various industries including biomedicine, fine chemicals production, drug delivery, packaging, and agriculture. This review provides the updated knowledge on the metabolic pathways for PHAs synthesis in bacteria, and the major microbial hosts for PHAs production. Yeasts are presented as a potential candidate for industrial PHAs production, with their high amenability to genetic engineering and the availability of industrial-scale technology. The major bottlenecks in the commercialization of PHAs as an alternative for plastics and future perspectives are also critically discussed.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
中午吃什么完成签到,获得积分10
1秒前
waiho完成签到,获得积分10
1秒前
JamesPei应助鳗鱼落雁采纳,获得10
1秒前
何浏亮完成签到,获得积分10
1秒前
yxq完成签到 ,获得积分10
2秒前
2秒前
糊涂的语兰完成签到,获得积分10
2秒前
清爽达完成签到 ,获得积分10
3秒前
ercha完成签到,获得积分10
3秒前
旅人完成签到,获得积分20
5秒前
Yubaibaio完成签到,获得积分10
6秒前
钟D摆完成签到 ,获得积分10
6秒前
希光光发布了新的文献求助10
6秒前
wwx完成签到,获得积分20
6秒前
111222完成签到,获得积分10
6秒前
潇湘学术完成签到,获得积分10
7秒前
油麦菜完成签到 ,获得积分10
7秒前
研友_8WzJOZ完成签到,获得积分10
8秒前
9秒前
陈雷应助真实的火车采纳,获得10
9秒前
wwx发布了新的文献求助10
9秒前
路寻完成签到,获得积分10
9秒前
12秒前
Zhangfu完成签到,获得积分10
12秒前
柠一完成签到 ,获得积分10
12秒前
jianjiao完成签到,获得积分10
13秒前
海丽完成签到 ,获得积分10
13秒前
阿铭完成签到 ,获得积分10
14秒前
DezhaoWang完成签到,获得积分10
14秒前
草莓熊和他的豆角完成签到,获得积分10
15秒前
赘婿应助科研疯狗采纳,获得10
15秒前
Maor完成签到,获得积分10
16秒前
16秒前
荀煜祺完成签到,获得积分10
17秒前
鳗鱼落雁发布了新的文献求助10
17秒前
细心的逍遥完成签到,获得积分10
18秒前
nuantong1shy完成签到,获得积分10
18秒前
二十八发布了新的文献求助20
20秒前
huyuan完成签到,获得积分10
21秒前
电闪完成签到,获得积分10
21秒前
高分求助中
Les Mantodea de Guyane Insecta, Polyneoptera 2500
Mobilization, center-periphery structures and nation-building 600
Technologies supporting mass customization of apparel: A pilot project 600
Introduction to Strong Mixing Conditions Volumes 1-3 500
China—Art—Modernity: A Critical Introduction to Chinese Visual Expression from the Beginning of the Twentieth Century to the Present Day 430
Multichannel rotary joints-How they work 400
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3795639
求助须知:如何正确求助?哪些是违规求助? 3340742
关于积分的说明 10301387
捐赠科研通 3057251
什么是DOI,文献DOI怎么找? 1677539
邀请新用户注册赠送积分活动 805488
科研通“疑难数据库(出版商)”最低求助积分说明 762626