泊洛沙姆
泊洛沙姆407
可扩展性
渗透
壳聚糖
色谱法
原位
化学
材料科学
聚合物
共聚物
生物化学
有机化学
膜
食品科学
作者
Deepika Modi,Mohammad,Musarrat Husain Warsi,Vaidehi Garg,Meenakshi Bhatia,Prashant Kesharwani,Gaurav Jain
标识
DOI:10.1080/09205063.2021.1932359
摘要
To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug. The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables. The optimized formulation was developed using 22.5 g PL and 0.3 g CS, gels at 33.6 °C, in 22.93 s, and showed the spreadability of 6.2 cm. In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution. The mechanism of release of TCS followed the Higuchi model with Fickian diffusion transport. Further, histopathology and HET-CAM studies revealed that the developed gel was non-irritating and safe for ocular administration.
科研通智能强力驱动
Strongly Powered by AbleSci AI