Role of CRISPR-Cas/9 in Hematological Disorders: A Review

The ongoing research in genome editing and gene silencing methods have paved a number of ways in not just detecting the diseases but also in rectifying it too. CRISPR Cas9 technology has been a gift in the field of genome editing technology. CRISPR Cas9 not only helps in identifying the diseases located in a particular gene but also helps in correcting the gene in its genome level by either silencing the gene for generations or replacing the defective gene and modifying it. With the help of CRISPR Cas9 replacing concept the defective gene is replaced with the new one and the disorder is not continued further. This advancement in the technology is the key benefit for the CRISPR Cas9 procedure. To add with it zincfinger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs)are the other two technology to contribute in genome editing too. Haematological disorders being lethal in nature have found a cure via CRISPR Cas9 technology.