AI-guided design of self-assembled flavonoid-cisplatin nanoparticles enhances triple-negative breast cancer therapy via three cell-death pathways

T-cell infiltration. In an orthotopic 4T1 model, they achieved a 71.5% reduction in tumor growth. This study establishes a language-model-driven framework for designing natural product-based, excipient-free nanomedicines, offering a scalable path to enhance chemotherapy while mitigating systemic toxicity.