A multifunctional nanocatalytic ferroptosis amplifier based on glutathione scavenging and lipid peroxidation amplification for cancer therapy

-glutathione (GSH)-GPX4 route, and hematoporphyrin monomethyl ether (HMME) enables SDT to generate ROS and lipid peroxides and eliminate heat resistance. This provides a novel strategy to address the self-hypoxic characteristics of tumor microenvironments, antioxidant defenses, and laser-responsive heat tolerance issues. In addition, it lays theoretical and experimental foundations for the application of iridium-based nano-drugs in cancer therapy enhanced by ferroptosis through amplified GSH depletion.