A Novel Thiazolidin-2-Cyanamide Derivative Suppresses Bacterial Blight by Targeting the Type III Secretion System and Reassembling a Protective Rice Leaf Microbiome

in healthy leaves. In healthy plants, higher II-2 doses preserved microbial stability, suggesting minimal ecological disturbance. II-2 exhibited no toxicity in silkworms or earthworms, functioning as a T3SS-targeting, microbiome-compatible antivirulence agent.