TGF-β/Smad信号传导通路在后囊膜混浊中用机制的研究进展

Posterior capsule opacification (PCO) is the frequent complication after cataract surgery.Transforming growth factor-β (TGF-β) is the important growth factor to modulate the transdifferentiation and formation of extracellular cell matrix (ECM) of cells.TGF-β modulates the proliferation,epithelial-mesenchymal transition and the formation of ECM by Smad signaling pathway.The research progress of TGF-β/Smad signaling pathway in PCO is reviewed in this article.