Different oncogenic potential in the mouse liver of mutant forms of the p110alpha catalytic subunit of phosphoinositide-3-kinase (PIK3CA)

PIK3CA, encoding the catalytic subunit p110α of class I phosphoinositide-3-kinase (PI3K), is mutated or overexpressed in many tumors, including hepatocellular carcinoma (HCC), where it is supposed to act as an oncogene. Here, we developed new mouse models to investigate the oncogenic effects of gain-of-function PIK3CA mutations and identified downstream PI3K signaling components in the mouse liver.