Dedicated AI Expert System vs Generative AI With Large Language Model for Clinical Diagnoses

In this diagnostic study comparing the performance of a traditional DDSS and current LLMs on unpublished clinical cases, in most cases, every system listed the case diagnosis in their top 25 diagnoses if laboratory test results were included. A hybrid approach that combines the parsing and expository linguistic capabilities of LLMs with the deterministic and explanatory capabilities of traditional DDSSs may produce synergistic benefits.