This chapter presents a comprehensive overview of desalination technologies and how these technologies can be integrated with renewable energy sources. The chapter draws attention to the vital role that water and energy play in human survival, as well as the growing pressure that is being placed on freshwater and energy delivery systems as a result of rapid population expansion. Desalination is a possible method to meet the need for high-quality water, a global concern. Water scarcity is a significant globally focused concern. The chapter discusses the environmental impacts of desalination, the distribution of Earth’s water, and the expansion of desalination plants. It also examines the energy requirements of different desalination processes and the potential of renewable energy sources to power these plants. The chapter concludes with case studies and future research opportunities, emphasizing the importance of sustainable desalination systems for addressing water scarcity.