A polarization independent highly sensitive metasurface-based biosensor for lab-on-chip applications

Metasurface-based sensors have emerged as an innovative technology in biosensing, offering enchanced sensitivity and versatility across a wide range of applications. In this study, we have proposed an asymmetric double T-shaped metasurface-based novel lab-on-chip and polarization-independent biosensor. Utilizing plasmonic metasurfaces for enhanced light-biomolecule interaction through near-field confinement effects, they enable streamlined processes, repeatability and reliability. Unlike surface plasmon resonance (SPR) sensors, metasurface-based sensors provide a comprehensive evaluation of plasmon parameters, significantly enhancing their analytical capabilities, which demonstrate exceptional stability, ensuring consistent and reliable results over time. The recorded sensitivity of the sensor is 1289.8 nm/RIU with a resolution of 7.753×10−7 RIU, which is capable of detecting minuscule changes in the refractive index of biomarkers. Our proposed novel sensor offers chemically stable and oxidization-free biosensing while ensuring rapid and selective diagnosis.