转移
癌症研究
肉碱
化学
生物
淋巴结
原发性肿瘤
β氧化
癌症
脂肪酸
医学
生物化学
内科学
作者
Yuan Li,Hongye Jiang,Yan Jia,Yuandong Liao,Chang‐Lun Shao,Yijia Zhou,Jiaying Li,Yan Lü,Hua Huang,Yuwen Pan,Weijia Wen,Xiaohan Zhao,Linna Chen,Jing Xu,Chaoyun Pan,Wei Wang,Shuzhong Yao,Chunyu Zhang
标识
DOI:10.1002/advs.202308422
摘要
Accumulating evidence indicates that metabolic reprogramming of cancer cells supports the energy and metabolic demands during tumor metastasis. However, the metabolic alterations underlying lymph node metastasis (LNM) of cervical cancer (CCa) have not been well recognized. In the present study, it is found that lymphatic metastatic CCa cells have reduced dependency on glucose and glycolysis but increased fatty acid oxidation (FAO). Inhibition of carnitine palmitoyl transferase 1A (CPT1A) significantly compromises palmitate-induced cell stemness. Mechanistically, FAO-derived acetyl-CoA enhances H3K27 acetylation (H3K27Ac) modification level in the promoter of stemness genes, increasing stemness and nodal metastasis in the lipid-rich nodal environment. Genetic and pharmacological loss of CPT1A function markedly suppresses the metastatic colonization of CCa cells in tumor-draining lymph nodes. Together, these findings propose an effective method of cancer therapy by targeting FAO in patients with CCa and lymph node metastasis.
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