双生的
立体专一性
部分
化学
正在离开组
光学活性
立体化学
功能群
群(周期表)
组合化学
有机化学
催化作用
聚合物
作者
Xinyi Chen,Feng-Chen Gao,Peng-Fei Ning,Yi Wei,Kai Hong
标识
DOI:10.1002/anie.202302638
摘要
Herein we reported a transition metal-free deborylative cyclization strategy, based on which two routes have been developed, generating racemic and enantioenriched cyclopropylboronates. The cyclization of geminal-bis(boronates) bearing a leaving group was highly diastereoselective, tolerating a few functional groups and applicable to heterocycles. When optically active epoxides were used as the starting materials, enantioenriched cyclopropylboronates could be efficiently prepared with >99 % stereospecificity. Mechanistic studies showed that the leaving group at the γ-position played a crucial role and significantly promoted the activation of the gem-diboron moiety.
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