Preliminary Histological Evidence of Epidermal and DEJ Remodeling with Microneedling-Assisted Topical Exosome Therapy: A Single-Subject Case Report

Microneedling-assisted topical exosome therapy produced notable structural improvements at the epidermal and dermoepidermal levels in aging skin. Restoration of rete ridges, enhanced keratinocyte proliferation, and increased collagen density suggest a promising role for this combined approach in skin rejuvenation. These findings are specific to microneedling-assisted topical delivery and should not be interpreted as supporting the use of injectable exosomes, which were not evaluated in this study.