微流控
纳米技术
个性化医疗
芯片上器官
微尺度化学
计算机科学
实验室晶片
工程类
生物信息学
生物
材料科学
数学教育
数学
作者
Umut A. Gürkan,David K. Wood,Dorn Carranza,Luke Herbertson,Scott L. Diamond,E. Du,Sudipto Guha,Jorge Di Paola,Pamela J. Hines,Ian Papautsky,Sergey S. Shevkoplyas,Nathan J. Sniadecki,Vamsee K. Pamula,Prithu Sundd,Afshan Rizwan,Pankaj Qasba,Wilbur A. Lam
出处
期刊:Lab on a Chip
[The Royal Society of Chemistry]
日期:2024-01-01
卷期号:24 (7): 1867-1874
摘要
Microfluidic lab-on-a-chip technologies enable the analysis and manipulation of small fluid volumes and particles at small scales and the control of fluid flow and transport processes at the microscale, leading to the development of new methods to address a broad range of scientific and medical challenges. Microfluidic and lab-on-a-chip technologies have made a noteworthy impact in basic, preclinical, and clinical research, especially in hematology and vascular biology due to the inherent ability of microfluidics to mimic physiologic flow conditions in blood vessels and capillaries. With the potential to significantly impact translational research and clinical diagnostics, technical issues and incentive mismatches have stymied microfluidics from fulfilling this promise. We describe how accessibility, usability, and manufacturability of microfluidic technologies should be improved and how a shift in mindset and incentives within the field is also needed to address these issues. In this report, we discuss the state of the microfluidic field regarding current limitations and propose future directions and new approaches for the field to advance microfluidic technologies closer to translation and clinical use. While our report focuses on using blood as the prototypical biofluid sample, the proposed ideas and research directions can be extrapolated to other areas of hematology, oncology, biology, and medicine.
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