铑
化学
催化作用
废止
转化(遗传学)
终端(电信)
对偶(语法数字)
组合化学
铵
立体化学
药物化学
有机化学
艺术
生物化学
文学类
计算机科学
基因
电信
作者
Tongxiang Fan,Zhipeng Shi,Qingguo Gong,Jin Song,Liu‐Zhu Gong
标识
DOI:10.1021/acs.orglett.4c00029
摘要
A dual rhodium/isothiourea catalytic system was developed for the enantiodivergent transformation of terminal alkynes. Under synergistic rhodium/isothiourea dual catalysis, terminal alkynes can be creatively utilized as precursors for C1-ammonium enolate species, which subsequently participate in [4 + 2] and [2 + 2] annulation reactions with α,β-unsaturated ketimines or ketones, respectively. A wide range of chiral lactams and lactones were obtained in excellent yields and stereoselectivities (up to >20:1 dr, 98% ee).
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