医学
氧化应激
抗氧化剂
活性氧
维生素E
失调
炎症
脂质代谢
疾病
免疫学
生物信息学
生物化学
内科学
生物
作者
Liana Trugilho,Livia Alvarenga,Ludmila F M F Cardozo,Ingrid Caroline Freitas Barboza,Maurilo Leite,Denis Fouque,Denise Mafra
标识
DOI:10.1016/j.clnesp.2023.12.147
摘要
Vitamin E is a lipid-soluble nutrient found mainly in vegetable oils and oilseeds. It is divided into eight homologous compounds; however, only α-tocopherol exhibits vitamin activity. Many advantages are related to these compounds, including cellular protection through antioxidant and anti-inflammatory activity, and improving lipid metabolism. Physiopathology of many diseases incepts with reduced antioxidant defense, characterized by an increased reactive oxygen species production and activation of transcription factors involved in inflammation, such as nuclear factor-kappa B (NF-κB), that can be linked to oxidative stress. Moreover, disorders of lipid metabolism can increase the risk of cardiovascular diseases. In addition, intestinal dysbiosis plays a vital role in developing chronic non-communicable diseases. In this regard, vitamin E can be considered to mitigate those disorders, but data still needs to be more conclusive. This narrative review aims to elucidate the mechanisms of action of vitamin E and if supplementation can be beneficial in a disease scenario regarding non-communicable diseases.
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