光热治疗
光动力疗法
生物相容性
单线态氧
材料科学
化学
纳米技术
氧气
有机化学
冶金
作者
Ruishen Meng,Ying Zhao,Hong‐Ying Xia,Shibin Wang,Ai‐Zheng Chen,Ranjith Kumar Kankala
出处
期刊:ACS materials letters
[American Chemical Society]
日期:2024-02-26
卷期号:6 (4): 1160-1177
被引量:1
标识
DOI:10.1021/acsmaterialslett.3c01615
摘要
The complexity of the cancer microenvironment makes it highly challenging for drugs to meet therapeutic requirements, significantly hampering their clinical translation. The enormous potential of intelligent materials that can act as drugs themselves results in the development of smart drugless or drug-like architectures, offering synergistic therapeutic effects. In this study, we demonstrate the generation of transition metal-based dichalcogenides (TMDCs)-based conformational (flower-like) nanoarchitectonics for synergistic trimodal therapies against breast carcinoma. Initially, the progressive transformation of two-dimensional (2D) molybdenum selenide (MoSe2)-based nanosheets into nanoflower-like architectures by the thermal injection method is observed with time. Further, these flowers are subsequently decorated with an optimal amount of platinum (Pt) nanoparticles for nanocatalytic efficacy and surface-modified with polyethylene glycol (PEG) for improved biocompatibility, shortly denoted as Pt-MoSe2-PEG for light-assisted photothermal (PTT) and photodynamic (PDT), as well as light-augmented chemodynamic (CDT) modalities. A series of physicochemical characterizations and performance validations successfully demonstrated the generation of tumor (pH/GSH)-responsive degradable nanoflower-like structures, substantially improving their ability of reactive oxygen species generation, MoSe2-based PTT/PDT capability, and light-augmented CDT efficacy of the Pt nanoenzymes. Finally, in vitro and in vivo investigations in the 4T1 cell line and its xenograft tumor model in BALB/C mice, respectively, validated the synergistic trimodal therapies of Pt-MoSe2-PEG toward ablating breast carcinoma.
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