乙型肝炎病毒
肝细胞癌
CD8型
生物
病毒
免疫学
细胞
病毒学
T细胞
肝细胞
抗原
免疫系统
医学
癌症研究
内科学
遗传学
作者
Banglun Pan,Zengbin Wang,Chen Rui,Xiaoxia Zhang,Jiacheng Qiu,Xiaoxuan Wu,Yuxin Yao,Yue Luo,Xiaoqian Wang,Nanhong Tang
标识
DOI:10.1128/spectrum.02860-23
摘要
Hepatitis B virus (HBV)-specific CD8+ T cells play a central role in the clearance of virus and HBV-related liver injury. Acute infection with HBV induces a vigorous, multifunctional CD8+ T cell response, whereas chronic one exhibits a weaker response. Our study elucidated HBV-specific T cell responses in terms of viral abundance rather than the timing of infection. We showed that in the premalignant stage, the degree of impaired T cell function was not synchronized with the viral surface antigen, which was attributed the liver's tolerance to the virus. However, after the development of hepatocellular carcinoma, T cell exhaustion was inevitable, and it was marked by the exhaustion of the signature transcription factor TOX.
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