全身炎症
炎症
医学
缺血
蛛网膜下腔出血
免疫系统
心脏病学
全身炎症反应综合征
内科学
免疫学
败血症
作者
Ho Jun Yi,Dong-Seong Shin,Bum‐Tae Kim
标识
DOI:10.1016/j.jstrokecerebrovasdis.2024.107626
摘要
Objectives Delayed cerebral ischemia (DCI) is a factor contributing to poor outcome of aneurysmal subarachnoid hemorrhage (aSAH). Serial inflammatory response is known to affect the occurrence of DCI. The aim of this study was to evaluate associations of dynamic changes of various inflammatory markers with occurrence of DCI after aSAH. Methods A total of 279 patients with interventional treatment for aSAH were enrolled, and dichotomized according to the occurrence of DCI. Various inflammatory markers, including systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and their dynamic changes were analyzed at four different time points. Receiver operating characteristic (ROC) curve analysis with area under the curve (AUC) and univariate, multivariate Cox regression analyses with hazard ratio (HR) and 95% confidence interval (CI) were performed to identify predictors for DCI. Results Differences of SII and SIRI values between DCI (+) and DCI (-) group were significantly higher at 5-7 days than at other time points (P < 0.001 and P < 0.001, respectively). SII and SIRI had higher predicting values for DCI occurrence than other inflammatory markers (AUC: 0.862, 95% CI: 0.786-0.928; P < 0.001 and AUC: 0.851, 95% CI: 0.769–0.913; P < 0.001, respectively). SII at 5-7 days (HR: 1.74, 95% CI: 1.38–3.22, P = 0.020) and SIRI at 5-7 days (HR: 1.62, 95% CI: 1.28–2.84, P = 0.035) were associated with occurrence of DCI. Conclusions Dynamic changes of SII and SII might be predictors of DCI occurrence in patients with aSAH.
科研通智能强力驱动
Strongly Powered by AbleSci AI