COMPARATIVE EFFECT OF INSULIN, GLIMEPIRIDE, AND METFORMIN ON INFLAMMATORY MARKERS IN TYPE 2 DIABETES MELLITUS.

Insulin, glimepiride, and metformin prescribe as monotherapy or in combination to control glycemic state. The present study aimed to identify the anti-inflammatory activity of commonly used antidiabetic medications insulin, glimepiride, and metformin if any. A follow-up study of added metformin alone or with glimepiride to newly diagnosed diabetic patients and add metformin to patients treated with insulin or glimepiride monotherapy to establish the effect on the glycemic and inflammatory state. There are highly significant differences in glycemic and inflammatory markers when adding metformin to newly diagnosed diabetic patients and when combined with insulin or glimepiride monotherapy. Metformin is associated with high anti-inflammatory action in addition to improving glycemic and lipidomics states.