Coordination‐Driven One‐Step Rapid Self‐Assembly Synthesis of Dual‐Functional Ag@Pt Nanozyme

Abstract Realizing high‐precise and adjustable regulation of engineering nanozyme is important in nanotechnology. Here, Ag@Pt nanozymes with excellent peroxidase‐like and antibacterial effects are designed and synthesized by nucleic acid and metal ions coordination‐driven one‐step rapid self‐assembly. The adjustable NA‐Ag@Pt nanozyme is synthesized within 4 min using single‐stranded nucleic acid as templates, and peroxidase‐like enhancing FNA‐Ag@Pt nanozyme is received by regulating functional nucleic acids (FNA) based on NA‐Ag@Pt nanozyme. Both Ag@Pt nanozymes that are developed not only has simple and general synthesis approaches, but also can produce artificial precise adjustment and possess dual‐functional. Moreover, when lead ion‐specific aptamers as FNA are introduced to NA‐Ag@Pt nanozyme, the Pb 2+ aptasensor is successfully constructed by increasing electron conversion efficiency and improving the specificity of nanozyme. In addition, both nanozyme has good antibacterial properties, with ~100% and ~85% antibacterial efficiency against Escherichia coli and Staphylococcus aureus , respectively. This work provides a synthesis method of novelty dual‐functional Ag@Pt nanozymes and successful application in metal ions detection and antibacterial agents.