生物
泛素连接酶
拟南芥
湿度
NPR1
物候学
卡林
F盒蛋白
水杨酸
细胞生物学
泛素
植物免疫
突变体
基因
生物化学
医学
心力衰竭
物理
利钠肽
内科学
热力学
作者
Li–Juan Yao,Zeyu Jiang,Yiping Wang,Yezhou Hu,Guodong Hao,Wei-Li Zhong,Shiwei Wan,Xiu-Fang Xin
标识
DOI:10.15252/embj.2023113499
摘要
Abstract The occurrence of plant disease is determined by interactions among host, pathogen, and environment. Air humidity shapes various aspects of plant physiology and high humidity has long been known to promote numerous phyllosphere diseases. However, the molecular basis of how high humidity interferes with plant immunity to favor disease has remained elusive. Here we show that high humidity is associated with an “immuno‐compromised” status in Arabidopsis plants. Furthermore, accumulation and signaling of salicylic acid (SA), an important defense hormone, are significantly inhibited under high humidity. NPR1, an SA receptor and central transcriptional co‐activator of SA‐responsive genes, is less ubiquitinated and displays a lower promoter binding affinity under high humidity. The cellular ubiquitination machinery, particularly the Cullin 3‐based E3 ubiquitin ligase mediating NPR1 protein ubiquitination, is downregulated under high humidity. Importantly, under low humidity the Cullin 3a/b mutant plants phenocopy the low SA gene expression and disease susceptibility that is normally observed under high humidity. Our study uncovers a mechanism by which high humidity dampens a major plant defense pathway and provides new insights into the long‐observed air humidity influence on diseases.
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