自愈水凝胶
姜黄素
普鲁兰
伤口愈合
甲基丙烯酸酯
化学
溶解度
成纤维细胞
环糊精
细胞毒性
体外
核化学
高分子化学
生物物理学
生物化学
聚合
有机化学
聚合物
外科
医学
多糖
生物
作者
Punnida Nonsuwan,Preeyaporn Plaimee Phiboonchaiyanan,Namon Hirun,Pakorn Kraisit
标识
DOI:10.1016/j.carbpol.2023.121294
摘要
A pullulan (Pul)-derivative hydrogel was developed by introducing methacrylate (MA) groups and β-cyclodextrin (βCD) to form a Pul-βCD-MA hydrogel by UV cross-linking. The MA was expected to improve the hydrogel's mechanical properties and the βCD to increase the solubility of curcumin. Pul-βCD-MA was successfully synthesized, as confirmed by the 1H NMR and FTIR spectra. Hydrogels were formed at Pul-βCD-MA concentrations of 5 %, 7.5 %, or 10 % w/v. Pul-βCD-MA showed enhanced curcumin solubility compared to Pul or Pul-MA. The morphological analysis of the hydrogel showed a porous structure. The concentration of βCD affected the hydrogels' mechanical properties, and the 7.5 % hydrogel (with or without curcumin) did not fracture. The cumulative release of curcumin in the 7.5 % Pul-βCD-MA hydrogel was 60 % over 8 h. The release profile fit the Korsmeyer-Peppas model. In vitro cytotoxicity tests revealed that hydrogels were biocompatible with human primary dermal fibroblast cells. Curcumin-loaded Pul-βCD-MA hydrogels significantly accelerated wound healing compared to Pul-βCD-MA hydrogels without curcumin loading. Therefore, the Pul derivative's hydrogel may be a promising material for wound healing.
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