CYP2D6型
三苯氧胺
基因分型
乳腺癌
医学
肿瘤科
内科学
基因型
等位基因
优势比
队列
药物遗传学
癌症
生物信息学
基因
遗传学
生物
细胞色素P450
新陈代谢
作者
Gabriel Sebastián Díaz Ramírez,Marius Vital,Carolina González Vergara,Florencia Carusso,Florencia Neffa,Adriana Della Valle,Patricia Esperón
出处
期刊:Personalized Medicine
[Future Medicine]
日期:2023-11-01
卷期号:20 (6): 477-483
标识
DOI:10.2217/pme-2023-0063
摘要
Aims: To report the distribution of allele frequencies of CYP2D6 gene and to evaluate their influence on the clinical outcomes of a group of breast cancer patients receiving adjuvant tamoxifen treatment from Uruguay. Patients & methods: 199 samples were genotyped through real-time polymerase chain reaction assays. Metabolization profiles were inferred from the genotypes. Correlations were evaluated using Pearson's χ 2 test. Results: Phenotype frequencies were 0.65 normal (NM), 0.30 intermediate (IM) and 0.05 poor metabolizers (PM). Similar clinical outcomes between NM and (PM + IM) patient groups (odds ratio = 1.011, 95% CI = 0.2703–3.7826; p = 0.987) were found. Conclusion: CYP2D6 allele frequencies were analyzed for the first time in a cohort from Uruguay. Results did not support any impact of CYP2D6 gene polymorphisms on clinical outcomes.
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