Closer to The Heart: Harnessing the Power of Targeted Extracellular Vesicle Therapies

Abstract Extracellular vesicles (EVs) have emerged as novel diagnostic and therapeutic approaches for cardiovascular diseases. EVs derived from various origins exhibit distinct effects on the cardiovascular system. However, the application of native EVs is constrained due to their poor stabilities and limited targeting capabilities. Currently, targeted modification of EVs primarily involves genetic engineering, chemical modification (covalent, non‐covalent), cell membrane modification, and biomaterial encapsulation. These techniques enhance the stability, biological activity, target‐binding capacity, and controlled release of EVs at specific cells and tissues. The diverse origins of cardioprotective EVs are covered, and the applications of cardiac‐targeting EV delivery systems in protecting against cardiovascular diseases are discussed. This review summarizes the current stage of research on the potential of EV‐based targeted therapies for addressing cardiovascular disorders.