单体
化学
立体化学
三醇
分子质量
组合化学
酶
生物化学
有机化学
聚合物
二醇
作者
Jae-Kyeong Kim,Mei He,Jae‐Seoun Hur,Jin Woo Lee,Kyo Bin Kang,Ki Sung Kang,Sang Hee Shim
标识
DOI:10.1021/acs.jnatprod.3c00468
摘要
Feature-based molecular networking analysis suggested the presence of naphthol tetramers in Daldinia childae 047219, the same species but a different strain from one used previously for the discovery of naphthol trimers promoting adiponectin synthesis. The new tetramers were composed of 5-methoxy-4-naphthol, each of which was connected to one another in various positions. Targeted isolation afforded six previously unreported naphthol tetramers (1–6) together with 13 known polyketides (7–19) including naphthol monomers, dimers, and trimers. Structures of the isolated compounds were established by using NMR and mass spectroscopic analysis. Nodulisporin A (13), nodulisporin B (14), and 1,1′,3′,3″-ternaphthalene-5,5′,5″-trimethoxy-4,4′,4″-triol (16) demonstrated anti-inflammatory activities against NO production, but the new compounds were less active.
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