Synthesis of amines

This chapter looks into nitrogen bases. Nitrogen compounds are widely used as bases in organic synthesis. The chapter also looks into the types of nitrogen bases such as tertiary amines and metal amides. It also discusses the reactions employing nitrogen bases by referencing the absence of base, concerted removal of a proton, and giving an anionic intermediate. Diazabicyclo amines can help a proton leave as part of a concerted reaction. Additionally, the chapter notes deprotonation is usually conducted at low temperatures. It explains the good bases for mopping up protons while the most popular base for deprotonation is lithium diisopropylamide (LDA).