Copper-doped cherry blossom carbon dots with peroxidase-like activity for antibacterial applications

Safety concerns arising from bacteria present a significant threat to human health, underscoring the pressing need for the exploration of novel antimicrobial materials. Nanozymes, as a new type of nanoscale material, have attracted widespread attention for antibacterial applications owing to their ability to mimic the catalytic activity of natural enzymes. In this work, we have constructed copper-doped cherry blossom carbon dots (Cu-CDs) with excellent peroxidase-like (POD) activity using a one-pot hydrothermal method. The utilization of cherry blossom as a natural material precursor significantly enhances its biocompatibility. Furthermore, the incorporation of copper ions initiates Fenton-like reaction-triggered POD-like catalytic activity, effectively eradicating bacteria by converting hydrogen peroxide (H₂O₂) into hydroxyl radicals (·OH). The antibacterial test results demonstrate that Cu-CDs exhibit a bactericidal efficacy of over 90% against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). This study presents a novel environmentally friendly nanozyme material derived from natural sources, exhibiting significant antimicrobial properties and offering innovative insights for the advancement of antimicrobial materials.