化学
半日花
根茎
传统医学
立体化学
萜类
医学
作者
Qing Zhao,Long-Gao Xiao,Li-Sha Bi,Yu Sui,Xiaomei Zhang,Jianhong Chen,Hai-Yang Liu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-09-21
卷期号:24 (38): 6936-6939
被引量:2
标识
DOI:10.1021/acs.orglett.2c02710
摘要
Hedychin E (1), a novel labdane-type norditerpenoid, and hedychin F (2), a new labdane-type dinorditerpenoid, were isolated from the rhizomes of Hedychium forrestii. Their structures were determined through a combination of spectroscopic analysis and X-ray single-crystal diffractions. Hedychin E (1) is an unprecedented 6-norditerpenoid with a fused tetrahydrofuran-lactone motif, and a reasonable biosynthetic pathway for 1 was proposed. Compound 2 showed a significant anti-inflammatory effect against LPS-induced NO production in macrophage RAW264.7 cells with an IC50 value of 21.0 μM.
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