医学
氧化应激
糖尿病性心肌病
糖尿病
内科学
心肌病
活性氧
炎症
内分泌学
药理学
心力衰竭
生物化学
化学
作者
Anees Ahmed Syed,Mohammad Irshad Reza,Mohammed Shafiq,Sanjana Kumariya,Roshan Katekar,Kashif Hanif,Jiaur R. Gayen
出处
期刊:Biomarkers
[Informa]
日期:2022-08-03
卷期号:27 (8): 743-752
被引量:3
标识
DOI:10.1080/1354750x.2022.2107703
摘要
Background Diabetic cardiomyopathy (DCM) is an age-related disease, and its progression is accompanied by hyperglycaemia, cardiac dysfunction, and myocardial structural and functional abnormalities. Cissus quadrangularis, a traditional medicinal plant, contains polyphenols, flavonoids, phytosterols, carbohydrates and ascorbic acid. It is used to treat osteoporosis, asthma, haemorrhoids and menstrual disorders.Objective: In the current research, we have investigated the effect of ethanolic extract of C. quadrangularis (EECQ) against a high-fat diet (HFD)/streptozotocin-induced DCM by estimating cardiac biomarkers, inflammatory markers and Reactive oxygen species (ROS) production.Material and methods Rats were fed with an HFD for 12 weeks, followed by single-shot low-dose streptozotocin (35 mg/kg; i.p.). The treatment was performed by EECQ (200 mg/kg/day, orally) for six weeks.Results The extract EECQ improves glucose, insulin tolerance tests and hypercholesteremia. DCM is characterized by cardiac dysfunction, cardiac biomarkers CKMB and LDH, which were attenuated by the EECQ treatment. The hypertrophic biomarker ANP, BNP expression and cardiomyocyte surface area were decreased by EECQ. Moreover, EECQ also alleviated the biomarkers Angiotensin II and renin level. EECQ also reduced oxidative stress, ROS production and cardiac inflammation.Conclusions Thus, these findings suggested that EECQ could be used as a possible therapeutic regiment to treat DCM.
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