Current State of mRNA Vaccine Development Against Mycobacterium tuberculosis

Tuberculosis (TB) disease caused by Mycobacterium tuberculosis (Mtb) is currently the second leading cause of death by a single infectious organism. Due to the increasing antimicrobial resistance (AMR) of Mtb, there is a high need for the development of more effective vaccines. In this chapter, we provide an in-depth overview of the potential of mRNA vaccines in the context of TB. Moreover, we present a comprehensive overview of the current state of the art and clinical development of mRNA vaccines against TB.