MiR-27a-5p deficiency in plasma exosomes derived from obese individuals exacerbates ventilator-induced lung injury in vitro and in vivo

Our findings suggest that the increased susceptibility of obese patients to VILI is likely, at least in part, due to a lack of miR-27a-5p in plasma exosomes. Targeting miR-27a-5p and its associated molecules may be a promising therapeutic avenue for preventing and treating VILI in obese patients.