SPP1 high macrophage-induced T-cell stress promotes colon cancer liver metastasis through SPP1/CD44/PI3K/AKT signaling

These findings reveal a previously unrecognized relationship between Macro_SPP1^high cells and HSPA1A^high/HSPA1B^high T cells in driving CCLM progression, suggesting a potential synergistic therapeutic approach that could boost immune checkpoint treatment efficacy in patients with CCLM.