Au-TiO2NANOSPHERES CATALYZED ONE-POT-MCR SYNTHESIS, CHARACTERIZATION AND ANTIPROLIFERATION ACTIVITY OF INDOLYL-IMIDAZOLOPYRIDINES CARBOXYLIC ACID HYBRIDS

In this context, we describe the efficiency of this catalyst towards green organic synthesis has been studied by carrying out a mixture of 1-fluoro-4-isocyanobenzene (1), 6-aminonicotinic acid (2)and substituted 1H-indole-3- carbaldehyde (3a-i) in distilled water, porous Au/TiO2nanospheres were added at room temperature in H2O. It proceeds yielding the corresponding isubstituted-3-((4-fluorophenyl) amino)-2-(1H-indol-3-yl)imidazo [1,2- a]pyridine-6-carboxylic acid derivative in good to excellent yield viz one-pot multi-component reaction. All the title compounds were also screened for Anti- proliferation activity screened for their in vitro anticancer activity against four human cancer cell lines MCF-7, HeLa, HEK 293T and IMR 32. Among them 4a (having 4-OCH3 substituent) has shown promising activity with IC50 (µM) 16.74±1.86 (MCF-7), 40.68 ± 1.25(HeLa), 50.61±4.64 (HEK 293T) and 26.58±1.68 (IMR32) has shown IC50 (µM) and these results are close to that of standard drug Doxorubicin.