预期寿命
医学
老年学
老化
心理干预
长寿
保健品
环境卫生
精神科
人口
内科学
病理
作者
Ben Dugan,Jessica M. Conway,Niharika Arora Duggal
出处
期刊:Age and Ageing
[Oxford University Press]
日期:2023-02-01
卷期号:52 (2)
被引量:21
标识
DOI:10.1093/ageing/afac328
摘要
Life expectancy has been on the rise for the past few decades, but healthy life expectancy has not kept pace, leading to a global burden of age-associated disorders. Advancing age is accompanied by a chronic increase in basal systemic inflammation, termed inflammaging, contributing towards an increased risk of developing chronic diseases in old age. This article reviews the recent literature to formulate hypotheses regarding how age-associated inflammaging plays a crucial role in driving chronic diseases and ill health in older adults. Here, we discuss how non-pharmacological intervention strategies (diet, nutraceutical supplements, phytochemicals, physical activity, microbiome-based therapies) targeting inflammaging restore health in older adults. We also consider alternative existing pharmacological interventions (Caloric restriction mimetics, p38 mitogen-activated protein kinase inhibitors) and explore novel targets (senolytics) aimed at combating inflammaging and optimising the ageing process to increase healthy lifespan.
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