遗传多样性
生物
病毒学
蜱传脑炎
黄病毒
滴答声
载体(分子生物学)
系统发育树
脑炎
病毒
遗传学
基因
人口
医学
环境卫生
重组DNA
作者
Kassandra L. Carpio,Jill C. Thompson,Steven G. Widen,Jennifer K. Smith,Terry L. Juelich,David E. Clements,Alexander N. Freiberg,Alan D.T. Barrett
出处
期刊:Viruses
[MDPI AG]
日期:2023-01-19
卷期号:15 (2): 281-281
被引量:3
摘要
The genetic diversities of mammalian tick-borne flaviviruses are poorly understood. We used next-generation sequencing (NGS) to deep sequence different viruses and strains belonging to this group of flaviviruses, including Central European tick-borne encephalitis virus (TBEV-Eur), Far Eastern TBEV (TBEV-FE), Langat (LGTV), Powassan (POWV), Deer Tick (DTV), Kyasanur Forest Disease (KFDV), Alkhurma hemorrhagic fever (AHFV), and Omsk hemorrhagic fever (OHFV) viruses. DTV, AHFV, and KFDV had the lowest genetic diversity, while POWV strains LEIV-5530 and LB, OHFV, TBEV-Eur, and TBEV-FE had higher genetic diversities. These findings are compatible with the phylogenetic relationships between the viruses. For DTV and POWV, the amount of genetic diversity could be explained by the number of tick vector species and amplification hosts each virus can occupy, with low diversity DTV having a more limited vector and host pool, while POWV with higher genetic diversities has been isolated from different tick species and mammals. It is speculated that high genetic diversity may contribute to the survival of the virus as it encounters these different environments.
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