Electrochemical Behavior of Ambroxol and Its Determination in Pharmaceutical Dosage Forms on MWCNT/Nafion Modified Glassy Carbon Electrodes

The electrochemical behavior of ambroxol was investigated on MWCNT/Nafion modified glassy carbon electrodes. In cyclic voltammetry, the compound showed an irreversible oxidation peak. Compared with the results on bare glassy carbon electrode and Nafion modified glassy carbon electrode, significant improvements in the sensitivity were obtained on MWCNT/Nafion modified glassy carbon electrode. The differential pulse voltammetric detection limits were determined to be 3×10-8 M, 4×10-9 M and 1 × 10-9 M on bare glassy carbon electrode, Nafion modified glassy carbon electrode and MWCNT/Nafion modified glassy carbon electrode, respectively. At the optimized condition, a sensitive linear differential pulse voltammetric response range for the ambroxol was between 1×10-8 and 1.8×10-6 M on MWCNT/Nafion modified glassy carbon electrode. Determination of ambroxol in pharmaceutical dosage forms was performed by differential pulse voltammetry. All values were in good statistical agreement with the nominal values.