金黄色葡萄球菌
抗生素
败血症
医学
菌血症
抗生素耐药性
抗菌剂
葡萄球菌感染
免疫系统
病菌
免疫学
微生物学
重症监护医学
生物
细菌
遗传学
出处
期刊:Pathogens and Disease
[Oxford University Press]
日期:2023-01-01
卷期号:81
被引量:1
标识
DOI:10.1093/femspd/ftad016
摘要
Staphylococcus aureus is the leading cause of hospital-acquired infections and can cause a wide range of diseases from mild skin infections to invasive diseases including deep surgical site infections, life-threatening bacteremia, and sepsis. This pathogen remains a challenge to manage due to its ability to rapidly develop resistance to antibiotic treatment and to form biofilms. Despite the current infection control measures which involve mainly antibiotics, the burden of infection remains high. The 'omics' approaches have not led to the discovery of novel antibacterials at a pace sufficient to cope with the emergence of multidrug-resistant and biofilm-forming S. aureus, Hence, new strategies for anti-infective therapies need to be explored urgently. One promising strategy is harnessing the immune response to enhance the protective antimicrobial immunity in the host. This review discusses the potential of monoclonal antibodies and vaccines as alternatives to treat and manage infections caused by planktonic and biofilms of S. aureus.
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