低潮区
化学
内酯
真菌
圆二色性
立体化学
细胞毒性
金属转移
Jurkat细胞
金属化
植物
有机化学
生物化学
水解
体外
生物
免疫系统
免疫学
T细胞
里氏木霉
纤维素酶
催化作用
作者
Lin Xu,Huabin Ma,Taizong Wu,Lifang Liu,Ming-Min Xie,Man-Yi Hu,Ying-Bao Gai,Tian-Hua Zhong,Xiong-Li Yang
标识
DOI:10.1002/cbdv.202300753
摘要
Chemical investigation of the deep-sea-derived fungus Hypocrea sp. ZEN14 afforded a new 3α-hydroxy steroidal lactone, hyposterolactone A (1) and 25 known secondary metabolites (2–26). The structure of the new compound was established by detailed spectroscopic analysis, electronic circular dichroism (ECD) calculation as well as a J-based configuration analysis. Compound 10 showed potent cytotoxicity against Huh7 and Jurkat cells with IC50 values of 1.4 μM and 6.7 μM, respectively.
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