Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus,Peroneutypasp.

Bioassay-guided investigation of the EtOAc-soluble extract of a culture of the marine-derived fungus Peroneutypa sp. M16 led to the isolation of seven new polyketide- and terpenoid-derived metabolites ( 1, 2, 4 – 8 ), along with known polyketides ( 3, 9 – 13 ). Structures of compounds 1, 2, and 4 – 8 were established by analysis of spectroscopic data. Absolute configurations of compounds 1, 2, 4, 6, 7, and 8 were determined by the comparison of experimental ECD spectra with calculated CD data. Compound 5 exhibited moderate antiplasmodial activity against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum .