赖氨酸
肽聚糖
噬菌体
生物
抗生素
微生物学
抗生素耐药性
计算生物学
生物技术
细菌
遗传学
大肠杆菌
基因
作者
Fatma Abdelrahman,Maheswaran Easwaran,Oluwasegun I. Daramola,Samar Ragab,Stephanie Lynch,Tolulope J. Oduselu,Fazal Mehmood Khan,Akomolafe Ayobami,Fazal Adnan,Eduard Torrents,Swapnil Ganesh Sanmukh,Ayman El‐Shibiny
出处
期刊:Antibiotics
[MDPI AG]
日期:2021-01-28
卷期号:10 (2): 124-124
被引量:91
标识
DOI:10.3390/antibiotics10020124
摘要
Due to the global emergence of antibiotic resistance, there has been an increase in research surrounding endolysins as an alternative therapeutic. Endolysins are phage-encoded enzymes, utilized by mature phage virions to hydrolyze the cell wall from within. There is significant evidence that proves the ability of endolysins to degrade the peptidoglycan externally without the assistance of phage. Thus, their incorporation in therapeutic strategies has opened new options for therapeutic application against bacterial infections in the human and veterinary sectors, as well as within the agricultural and biotechnology sectors. While endolysins show promising results within the laboratory, it is important to document their resistance, safety, and immunogenicity for in-vivo application. This review aims to provide new insights into the synergy between endolysins and antibiotics, as well as the formulation of endolysins. Thus, it provides crucial information for clinical trials involving endolysins.
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