CYP2D6型
生物等效性
药代动力学
阿立哌唑
医学
药理学
药物遗传学
基因型
人口
多态性(计算机科学)
内科学
单核苷酸多态性
等位基因
生物
遗传学
基因
精神分裂症(面向对象编程)
细胞色素P450
精神科
新陈代谢
环境卫生
作者
Xiaodan Zhang,Chengquan Liu,Shuang Zhou,Ran Xie,Xu He,Zhiqi Wang,Honghong Yi,You Shu,Zining Wang,Kun Hu,Lingyue Ma,Yimin Cui,Xia Zhao,Jin Xiang
出处
期刊:Pharmacogenomics
[Future Medicine]
日期:2021-02-15
卷期号:22 (4): 213-223
被引量:3
标识
DOI:10.2217/pgs-2020-0134
摘要
Background: Pharmacogenetics study was added into 2 bioequivalence trials of aripiprazole. The correlation between CYP2D6 polymorphisms and aripiprazole pharmacokinetics (PK) was analyzed. Materials & methods: A total of 140 subjects were included. A total of 26 CYP2D6 gene alleles were detected. The plasma concentration of aripiprazole was measured by liquid chromatography-tandem mass spectrometry. SPSS Statistics 21 was used to analyze the correlation between CYP2D6 polymorphisms and aripiprazole PK parameters. Results: All of the four PK parameters were significantly influenced by CYP2D6rs1058164 and rs28371699. t1/2 and area under the concentration-time curve exhibited significant difference between CYP2D6 extensive metabolizers and intermediate metabolizers. Conclusion: Aripiprazole PK was greatly influenced by CYP2D6. Attention should be paid to the possible dose adjustment for CYP2D6 intermediate metabolizer population when the drug is used in Chinese patients.
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