代谢组学
氨基酸
丙氨酸
新陈代谢
缺血
代谢途径
化学
乳酸
药理学
急性肾损伤
氨基酸代谢
生物化学
脂质代谢
肾
医学
内科学
生物
细菌
色谱法
遗传学
作者
Shuyi Shen,Wang Jf,Jing Wu,Zhou Jx,S-D Meng,Juan Ma,Chuhong Zhu,G-G Deng,D Liu
出处
期刊:PubMed
日期:2017-02-01
卷期号:21 (4): 765-774
被引量:4
摘要
Dysfunctional metabolisms have contributed towards ischemia-reperfusion (I/R) injury. However, the role of remote ischemic preconditioning (RIP) in I/R injury is not well known. The present study showed alleviated I/R injury in kidneys treated with RIP.We utilized GC/MS-based metabolomics to characterize the variation of metabolomes.Metabolic category using differential metabolites showed the lower percentage of amino acids in I/R group in comparison to RIP+I/R group, confirming the importance of amino acid metabolism in RIP-treated rat kidney. Further, pathway enrichment analysis showed alanine, aspartate and glutamate metabolism to be involved in the beneficial effects of RIP during renal I/R injury. Furthermore, another crucial enrichment pathway is biosynthesis of unsaturated fatty acids. Other vital metabolites detected in independent component analysis (ICA) analysis were d-glucose, lactic acid and cholesterol. The variation tendency of above-mentioned metabolites was overall consistent with the protective nature of RIP.These findings elicited a viewpoint that metabolic strategy affected by RIP are linked to underlying mechanisms of RIP and highlighted the importance of metabolic strategy against I/R injury.
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